Grant: Formulation for 3D printing: Creating a plug and play platform for a disruptive UK industry
PI: Professor Ricky Wildman, University of Nottingham

Presentation: Formulation for 3D printing - pdf
Prof Ricky Wildman, University of Notttingham

We will show how we can tackle materials synthesis, formulation and selection in a systematic way such that we can create libraries of materials with known functionalities ready for use in a range of industrial sectors. A number of different levers to being able to control function will be illustrated. This will include varying the geometry, the material, the distribution of material and the microstructure. I will also show how we can describe the development of properties computational such that we can create a design tool that will inform both the composition and the curing strategy that should be employed to achieve the outcome that we desire.


Question (Pedro Torres): @Ricky, is the geometry of the nozzle used in printing another lever? If so, how important do you think it is?

Verbally answered

Question (Simon Gibbon): @Ricky are you able to dial up a range of release profiles (zero order, first order, etc..) based purely on physical properties of your ingredients?

Response (Ricky Wildman): Hi Simon, yes we believe that we can access the whole range of profiles by tuning the microstructure and/or the material composition. It is also possible to create depot type structures with a rate controlling membrane using multilmaterial printing.

Poster: A 3D printed polymeric drug-eluting implant - pdf
Athina Liaskoni, University of Nottingham

Conventional drug delivery systems, tablets, capsules and solutions can be limited for the treatment of some diseases. Their necessary frequent administration can be unpleasant to patients and their compliance can be reduced. Implants, and personalized implants in particular can offer a solution and 3D printing is a novel method of manufacture of such systems. This study aims to investigate the 3D printing of persinalisable lidocaine loaded polycaprolactone implants using an extrusion-based 3D printer. In this approach, patients will only need one drug delivery systems which will contain the exact dosages of the active ingredients they need. During the printing, different settings have been applied for the fabrication of the drug loaded polymeric implants following optimisation for the used materials. Physical and chemicial characterisation before and after 3D printing were carried out to investigate potential changes in material peroperties. The drug release rate of teh differently printed formulations has been evaluated. It has been shown that the manufacture of drug loaded polycaprolactone implants using a solvent-free method, without the addition of any excipients and at relatively low printing temperature with an extrusion-based 3D printer is feasible. Therefore, this 3D printing method represents a promising technology for the production of personalisable drug-eluting implants.

Poster: Jet mixing - towards continuous production of core-shell particles for additive manufacture - pdf
Marica Malenica, University of Nottingham


RSC FST Future Formulation IV - The Conference

Grant Page: Predictive formulation of high-solid-content complex dispersions
PIs: Dr Jin Sun, University of Edinburgh & Dr Mark Haw, University of Strathclyde

Grant Page: Virtual Formulation Laboratory for prediction and optimisation of manufacturability of advanced solids based formulations
PI: Dr Csaba Sinka, University of Leicester

Grant Page: Evaporative Drying of Droplets and the Formation of Micro-structured and Functional Particles and Films
PI: Professor Colin Bain, Durham University

Grant Page: Enabling rapid liquid and freeze-dried formulation design for the manufacture and delivery of novel biopharmaceuticals
PIs: Dr Robin Curtis, The University of Manchestr & Professor Paul Dalby, University College London

Grant Page: Complex ORAL health products (CORAL): Characterisation, modelling and manufacturing challenges
PI: Professor Panagiota Angeli, University College London

Grant Page: Formulation for 3D printing: Creating a plug and play platform for a disruptive UK industry
PI: Professor Ricky Wildman, University of Nottingham

Grant Page: INFORM 2020 - Molecules to Manufacture: Processing and Formulation Engineering of Inhalable Nanoaggregates and Microparticles
PI: Professor Darragh Murnane, University of Hertfordshire