Challenges of assessing number-based particle concentration and the development of a quantitative method using DCS - poster
Beth A. Hinchliffe1, Annhelen Lu2, Mohammed Alkattan2, Caterina Minelli1
1 National Physical Laboratory, Hampton Road, Teddington, Middlesex, TW11 0LW, UK
2 OxSonics Therapeutics, The Magdalen Centre, Oxford Science Park, Oxford, OX4 4GA
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Number-based particle concentration is an important attribute of industrial particle formulations which enable assessment of product batch-to-batch variability, and measurement of dosage for therapeutic and medical applications. However, its measurement accuracy and precision remain a challenge to industry due to the lack of relevant reference materials and standards. Collaboration between OxSonics and NPL has resulted in the development of a method to measure number-based particle concentration using Differential Centrifugal Sedimentation (DCS), with lower variability than reported by Particle Tracking Analysis (PTA).