Speakers Abstracts and Biography
Professor Majella Lane
Title:- Application of Confocal Raman Spectroscopy in personal care formulation
Abstracts
Confocal Raman spectroscopy (CRS) is a non-invasive method that combines the principles of confocal microscopy and Raman spectroscopy to enable high analytical spatial resolution and sensitivity. CRS is a powerful tool in skin research as it can provide detailed information about the molecular composition of the skin as a function of depth. Additionally, it enables the determination of skin uptake of topically applied substances in real time in vitro and in vivo without sample pre-treatment or labelling. This presentation will review our experience with CRS over the years for investigation of delivery of molecules to the skin following topical application. Most recently we have investigated the quantitative capability of CRS in vivo and demonstrated excellent correlations with the well-established in vitro Franz-diffusion cell model. As rational formulation design is predicated on identifying those vehicle components that are optimal for a specific active, we have also examined excipient delivery in skin with CRS. We believe that CRS will prove a reliable, fast, and non-invasive method to assess formulation efficacy thus facilitating cost-effective and accelerated product development.
Biography
Majella holds a degree in pharmaceutical science and a PhD in membrane transport. Her major areas of expertise include delivery of actives to and through the skin, biophysical approaches towards the elucidation of active-skin and formulation-skin interactions, mechanisms of active absorption in skin and topical formulation design and evaluation. To date she has published more than 170 peer-reviewed papers, supervised 30 PhD students, and mentored 15 postdoctoral research associates. Majella also acts as a consultant to many multinational companies. She is the Editor-In-Chief of the International Journal of Cosmetic Science and she serves on the editorial board of a number of cosmetic and pharmaceutical science journals. In 2020 Majella was appointed to the Council of the Society of Cosmetic Scientists of the United Kingdom. Her research group collaborates worldwide and she also hosts visiting scientists from academia and industry in her laboratory.
James Holloway
Title:- Making “light” work of Cosmetics Testing
Abstract
I will present the latest developments in the use of near-infrared light to measure the stability of emulsions, suspensions, dispersions, and foams with NO sample preparation. Reducing testing times by 50 – 200x ensures that formulation work can be significantly reduced, whilst ensuring an excellent shelf-life. The new TSi (Turbiscan® Stability Index) provides instant one-click comparisons between samples, allowing the rapid screening of new raw materials.Real world examples will be given including product / packaging interactions, as well as the determination of the foamability of different products.
Biography:
I studied Chemistry at Nottingham University and worked in research and development for 7 years, before moving to technical sales. I have an expertise in using light to measure concentrated systems in both the laboratory and process environments.
Ron Savin – Anton Paar Ltd
Title: – Determination of the physical properties of cosmetic and pharmaceutical products
Biography:
Ron is an instrumentation engineer and product manager for volatility and consistency instruments with Anton Paar. His areas of expertise include physical characterisation of materials and ingredients using density, viscosity, refractive index and optical rotation. He has also worked extensively with universities and manufacturers in the field of oxidation stability measurement for product development & quality control.
https://www.linkedin.com/in/ron-savin-2957b083/
Anton Paar Ltd
Anton Paar are known world wide for high-end instrumentation. Areas of speciality include world leading technology for fluids measurement covering density, viscosity, refractive index, optical rotation, particle sizing and rheological properties. Other products areas include Petroleum Testing, Microwave Synthesis, Sample Preparation and Material Characterization.
Used across manufacturing, research and the academic sectors. Their instruments are known for their ease of use, robust construction and high precision. A core competence in high-precision production and close contact with the scientific community form the basis of their quality and innovation. This expertise is backed by a presence in over 80 countries offering local technical and application support.
Carol Treasure, – XCellR8
Title – Better Science, Better Ethics: 100% animal-free cosmetic safety testing approaches
Abstract
Many in vitro tests still use animal derived components such as serum, tissue extracts and antibodies. There is an increasing body of evidence that demonstrates the importance of having a system which models human physiology as closely as possible, rather than relying on the use of animal-based culture systems. The significant ethical issues surrounding the use of animal-derived components, especially FBS, have also been well documented. XCellR8 have always taken the view that the use of any animal components undermines the validity of ‘not tested on animals’ and vegan claims and we eliminated the use of animal products in our laboratory from the very beginning.
Understanding the animal-free status of in vitro tests is important for cosmetic products formulators and ingredients manufacturers. We will discuss our 7-point scale for animal-product-free (APF) testing and how it can be used as a tool to aid decision making about which tests are acceptable. The scale clearly shows a progression from the use of animals or components that cause animal sacrifice or suffering, through to waste products (eg from the meat industry) and human-based alternatives, finally progressing to fully APF, defined in vitro systems
We will also present our research and developments to adapt existing safety tests, where all animal components have been eliminated, to use human-derived serum and antibodies from approved sources as well as completely chemically defined products. This approach maximises both the human relevance and reproducibility of the test results.
Biography:
Dr Carol Treasure is the Founder and CEO of XCellR8, an animal-free testing laboratory. XCellR8 conduct regulatory in vitro safety and efficacy tests for global cosmetic companies and ingredient manufacturers. Carol founded XCellR8 in 2008 with a mission to accelerate the world’s transition to 100% animal-free testing and the company’s work has been recognised at a regulatory level by the OECD and by top funding bodies such as Innovate UK and Horizon 2020.
Carol holds a first degree in Physiology and Pharmacology from the University of Sheffield, and a PhD from the FRAME Alternatives Laboratory at University of Nottingham, based on skin cell biology and reconstructed skin models for cosmetics testing. She has devoted her career to using innovative science to replace animal testing over the past 25 years.
