Dr. Leonardo Borras
Alcon Labs (Novartis company) – leonardo.borras@alconlabs.com The Importance of Early Biophysical Characterization of Antibodies in the Lead Selection Process A critical aspect of the antibody lead selection process is assessing and understanding the biophysical properties of antibody lead candidates. An early characterization helps to reduce or eliminate development issues while allowing for ideal lead selection. We have […]
Susanne Jörg
Novartis Pharma AG, Switzerland – susanne.joerg@novartis.com Special aspects in the pharmaceutical development of protein formats beyond mAbs In the past decades, monoclonal antibodies have become the fastest growing area of biopharmaceutical industry. Currently, alternative protein formats – such as FAbs, scFvs, nanobodies, etc – are under development. These new antibody and therapeutic protein formats come along with […]
Avacta
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GE Healthcare
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Malvern Instruments
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Nanosight
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An atomic force microscopy based method for biopharmaceutical stability determination
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Prof. Mike Williamson
Dept of Molecular Biology and Biotechnology, University of Sheffield – m.williamson@sheffield.ac.uk Taming protein interactions All proteins have evolved to interact, and in most cases this interaction is with other proteins. Sometimes the interactions are strong, but more often they are weak (Kd > 10 μM), especially in the crowded environment of the cell. Such interactions are […]
Professor Michele Vendruscolo
Cambridge University – mv245@cam.ac.uk Sequence-based prediction of protein solubility As increasing evidence indicates that the sequences of proteins encode not just their folding but also their solubility and aggregation [1,2], there is great interest in identifying the amino acid code responsible for the maintenance of solubility. We have been developing computational methods to predict different aspects of […]
Protein Simple
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