Dr. Natalia Markova
GE Healthcare – Natalia.Markova@ge.com Use of ITC/DSC for the studies of biomolecular stability and interaction of excipients with proteins Stability of liquid protein formulation is critical for achieving desired therapeutic effect during prolonged storage of biopharmaceuticals. Our ability to predict factors critical to protein stability is limited due to a complex nature of proteins and a […]
Protein Simple
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Dr. Paul A. Dalby
Dept Biochemical Engineering, UCL, London UK – p.dalby@ucl.ac.uk Screen early – fail early: Rapid analytical screens for protein formulation Biophysical analyses are essential for understanding the effect of formulation excipients on protein stability. However, most are not accessible for small quantities of precious materials or for higher-throughput analyses. Microscale and microfluidic platforms are enabling small quantities […]
The Evaluation of High Throughput Apparent Solubility and Conformation Assays as Predictive Tools for Early Stage Formulation Development
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Inhalable formulations loaded with therapeutic protein constructs
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Biosensor and chromatography based strategies for high throughput measurement of protein self-association during formulation development
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Protein Stabilisers: New Opportunities from Patent Expiry
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The Development of a Systematic Coarse-Grain Model for Polymer Drug Encapsulation
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Protein crystals as formulations for protein delivery
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Use of Dynamic Mechanical Analysis and Dynamic Scanning Calorimetry in the Determination of Critical Temperature Parameters for the Stabilization of Freeze-dried Biologicals
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